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Article

LEPR gene polymorphisms and pneumonia risk in Taiwanese schizophrenia patients under clozapine treatment.

Schizophrenia research - 1 Apr 2025

Huang Hui-Ching, Wu Bo-Jian, Yu Chuan-Hsun, Liu Chao-Zong, Wu Lawrence Shih-Hsin

Abstract excerpt

BACKGROUND: Clozapine, the preferred medication for treatment-resistant schizophrenia, elevates leptin and pro-inflammatory cytokine levels in patients' blood. Inhibition of the clozapine metabolic enzyme CYP1A2 can potentially lead to toxicity and pneumonia. Leptin has a pro-inflammatory effect on the immune system. This study explores whether polymorphisms in the leptin (LEP) and leptin receptor (LEPR) genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40081291
DOI: 10.1016/j.schres.2025.03.014

Genes

LEPR
LEP
CYP1A2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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