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Article

Polymorphisms of the LEP- and LEPR genes, metabolic profile after prolonged clozapine administration and response to the antidiabetic metformin.

Schizophrenia research - 1 Aug 2010

Fernández Erika, Carrizo Edgardo, Fernández Virginia, Connell Lisette, Sandia Ignacio, Prieto Dexy, Mogollón Johana, Valbuena Dennys, Fernández Iliana, de Baptista Enma Araujo, Baptista Trino

Abstract excerpt

BACKGROUND: The role of leptin in atypical antipsychotic-induced metabolic dysfunction was explored by assessing the anthropometric and metabolic profile and the response to metformin (MET) of clozapine- (CLZ) treated schizophrenia patients according to their single nucleotide polymorphisms (SNPs) in the leptin promoter (LEP2548/GA) and leptin receptor (LEPR Q223R) genes. METHODS: Phase 1. Body mass index (BMI),...

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Source

Identifiers

PMID: 20591628
DOI: 10.1016/j.schres.2010.06.001

Genes

MET
LEPR
LEP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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