Pharmacogenomic and inflammatory determinants of antipsychotic-induced extrapyramidal toxicity in Egyptian patients with schizophrenia.

doi:10.1080/17425255.2026.2660702

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Pharmacogenomic and inflammatory determinants of antipsychotic-induced extrapyramidal toxicity in Egyptian patients with schizophrenia.

Expert opinion on drug metabolism & toxicology - 1 Mar 2026

Ahmed Asmaa Mohamed Sayed, Moawad Asmaa Mohammad, Tarek Mennat-Allah, Abdelgwad Marwa, Aboutaleb Alaa Mohamed Ibrahim, Abouelkheir Abrar Roshdy

Abstract excerpt

BACKGROUND: Extrapyramidal symptoms (EPS) are side effects of antipsychotic therapy, and genetic and inflammatory mechanisms may contribute to EPS risk. This study investigated the associations among ABCC2 (rs4148396) gene polymorphisms, serum interleukin-6 (IL-6) levels, and risperidone-induced EPS among patients with schizophrenia. RESEARCH DESIGN AND METHODS: This cross-sectional association study utilized a...

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PMID: 41979116
DOI: 10.1080/17425255.2026.2660702

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ABCC2

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