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Article

Genetic polymorphisms of HTR2C, LEP and LEPR on metabolic syndromes in patients treated with atypical antipsychotic drugs.

The Journal of pharmacy and pharmacology - 1 Apr 2018

Puangpetch Apichaya, Unaharassamee Weerapon, Jiratjintana Napa, Koomdee Napatrupron, Sukasem Chonlaphat

Abstract excerpt

OBJECTIVE: Single nucleotide polymorphisms in serotonin 2C receptor (HTR2C), leptin (LEP), and leptin receptor (LEPR) genes are reportedly associated with the presence of metabolic syndrome (MS). We investigated whether HTR2C:rs518147 (-697G/C), rs12836771 (A/G), LEP: rs7799039 (-2548G/A) and LEPR:rs1137101 (668A/G) are related to MS in psychotic disorder patients treated with atypical antipsychotics. METHODS: A...

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Share to Antipsychotic Agents
Share to Cross-Sectional Studies
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Share to Metabolic Syndrome
Share to Polymorphism, Single Nucleotide
Share to Receptor, Serotonin, 5-HT2C
Share to Receptors, Leptin
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Source

Identifiers

PMID: 29441581
DOI: 10.1111/jphp.12892

Genes

LEP
LEPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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