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Article

Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.

Molecular and cellular biology - 1 Nov 2000

Solsbacher J, Maurer P, Vogel F, Schlenstedt G

Abstract excerpt

Import of proteins containing a classical nuclear localization signal (NLS) into the nucleus is mediated by importin alpha and importin beta. Srp1p, the Saccharomyces cerevisiae homologue of importin alpha, returns from the nucleus in a complex with its export factor Cse1p and with Gsp1p (yeast Ran) in its GTP-bound state. We studied the role of the nucleoporin Nup2p in the transport cycle of Srp1p. Cells lacking...

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Identifiers

PMID: 11046143
DOI: 10.1128/MCB.20.22.8468-8479.2000
PMCID: PMC102153

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha.PMID 11046143Read ↗

Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase.Semantic proximity Read ↗

Cse1p is involved in export of yeast importin alpha from the nucleus.Semantic proximity Read ↗

The NUP1 gene encodes an essential component of the yeast nuclear pore complex.Semantic proximity Read ↗

Genetic and physical interactions between Srp1p and nuclear pore complex proteins Nup1p and Nup2p.Semantic proximity Read ↗

Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus.Semantic proximity Read ↗

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex.Semantic proximity Read ↗

The yeast nucleoporin Nup53p specifically interacts with Nic96p and is directly involved in nuclear protein import.Semantic proximity Read ↗

Mutations affecting spindle pole body and mitotic exit network function are synthetically lethal with a deletion of the nucleoporin NUP1 in S. cerevisiae.Semantic proximity Read ↗

A subset of FG-nucleoporins is necessary for efficient Msn5-mediated nuclear protein export.Semantic proximity Read ↗

A lack of SUMO conjugation affects cNLS-dependent nuclear protein import in yeast.Semantic proximity Read ↗

The Ran GTPase cycle is required for yeast nuclear pore complex assembly.Semantic proximity Read ↗

Nuclear accumulation of the small GTPase Gsp1p depends on nucleoporins Nup133p, Rat2p/Nup120p, Nup85p, Nic96p, and the acetyl-CoA carboxylase Acc1p.Semantic proximity Read ↗

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