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Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics

7 Mar 2025

Abstract excerpt

A central question in cell and developmental biology is how extracellular cues control the differentiation of multipotent progenitors in a dynamically changing niche. Here, we identify apical-basal polarity as the main regulator of the differentiation of multipotent pancreatic Neurogenin3 + endocrine progenitors (EPs) into the beta or alpha cell fates. We show that human EPs dynamically change their apical-basal...

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PMID: 40056911
DOI: 10.1016/j.devcel.2025.02.008

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