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Article

ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids

17 Feb 2020

Abstract excerpt

OBJECTIVE: Enteroendocrine cells (EECs) survey the gut luminal environment and coordinate hormonal, immune and neuronal responses to it. They exhibit well-characterised physiological roles ranging from the control of local gut function to whole body metabolism, but little is known regarding the regulatory networks controlling their differentiation, especially in the human gut. The small molecule isoxazole-9...

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PMID: 32180555
DOI: 10.1016/j.molmet.2020.01.012

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