Article
Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes.
Annals of clinical and translational neurology - 1 May 2025
Zhang Hanwen, Kargilis Daniel, Tropea Thomas, Robinson John, Shen Junchao, Brody Eliza M, Brinkmalm Ann, Sjödin Simon, Berndt Adama J, Carceles-Cordon Marc, Suh EunRan, Van Deerlin Vivianna M, Blennow Kaj, Weintraub Daniel, Lee Edward B, Zetterberg Henrik, Chen-Plotkin Alice S
Abstract excerpt
OBJECTIVE: Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome-wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function. METHODS: Starting with 525 candidate gene-single nucleotide polymorphism (SNPs) pairs nominated by Mendelian...
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