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Commander complex regulates lysosomal function and is implicated in Parkinson’s disease risk

10 Apr 2025

Abstract excerpt

Variants in GBA1 resulting in decreased lysosomal glucocerebrosidase (GCase) activity are a common risk factor for Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Incomplete penetrance of GBA1 variants suggests that additional genes contribute to PD and DLB manifestation. By using a pooled genome-wide CRISPR interference screen, we identified copper metabolism MURR1 domain–containing 3 (COMMD3)...

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PMID: 40209002
DOI: 10.1126/science.adq6650

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