Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data.

Journal of neurology - 1 Aug 2023

Gu Xiao-Jing, Su Wei-Ming, Dou Meng, Jiang Zheng, Duan Qing-Qing, Wang Han, Ren Yan-Ling, Cao Bei, Wang Yi, Chen Yong-Ping

Abstract excerpt

BACKGROUND: Genome-Wide Association Studies (GWAS) have identified numerous risk genes for Amyotrophic Lateral Sclerosis (ALS); however, the mechanisms by which these loci confer ALS risk are uncertain. This study aims to identify novel causal proteins in the brains of patients with ALS using an integrative analytical pipeline. METHODS: Using the datasets of Protein Quantitative Trait Loci (pQTL) (NpQTL1 = 376,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Bayes Theorem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Proteome

Source

Identifiers

PMID: 37148340
DOI: 10.1007/s00415-023-11757-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identifying novel genes for amyotrophic lateral sclerosis by integrating human brain proteomes with genome-wide association data.PMID 37148340Read ↗

Abnormal brain protein abundance and mRNA expression of SARM1 in amyotrophic lateral sclerosisSemantic proximity Read ↗

Causal Inference of Genetic Variants and Genes in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Prioritization of therapeutic targets for amyotrophic lateral sclerosis using protein-wide Mendelian randomization analysisSemantic proximity Read ↗

Harnessing transcriptomic signals for amyotrophic lateral sclerosis to identify novel drugs and enhance risk predictionSemantic proximity Read ↗

Harnessing Transcriptomic Signals for Amyotrophic Lateral Sclerosis to Identify Novel Drugs and Enhance Risk PredictionSemantic proximity Read ↗

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell typesSemantic proximity Read ↗

Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types.Semantic proximity Read ↗

Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analysesSemantic proximity Read ↗

SCFD1 expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressedSemantic proximity Read ↗

A Genome-wide Expression Association Analysis Identifies Genes and Pathways Associated with Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Genome-wide association analysis reveals potential genetic correlation and causality between circulating inflammatory proteins and amyotrophic lateral sclerosis.Semantic proximity Read ↗

Identifying Candidate Genes Associated with Sporadic Amyotrophic Lateral Sclerosis via Integrative Analysis of Transcriptome-Wide Association Study and Messenger RNA Expression Profile.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.