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Article

The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis

11 Oct 2011

Abstract excerpt

The locus ceruleus is among the earliest affected brain regions in Parkinson's disease (PD) showing Lewy body pathology and neuronal loss. To improve our understanding of the pathogenesis of PD, we performed the first proteomic analysis ever of post-mortem locus ceruleus tissue of six pathologically confirmed PD patients, and six age- and gender-matched non-neurological controls. In total 2495 proteins were...

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PMID: 21988495
DOI: 10.1111/j.1750-3639.2011.00540.x

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