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Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anticancer Cytotoxicity in Breast Cancer

7 Mar 2025

Abstract excerpt

Cancer-associated fibroblasts (CAF) are abundant components of the breast tumor microenvironment and major contributors to immune-modulation. CAFs regulate the activity of many immune cells including T cells, macrophages, and dendritic cells; however, little is known about their interaction with NK cells, which constitute an important arm of antitumor immunity. Using mouse models of breast cancer and ex vivo...

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PMID: 40052789
DOI: 10.1158/2159-8290.cd-24-0131

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