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Article

Resident memory CD8+ T cells within cancer islands mediate survival in breast cancer patients

29 Aug 2019

Abstract excerpt

CD8+ tumor-infiltrating lymphocytes (TILs) correlate with relapse-free survival (RFS) in most cancer types, including breast cancer. However, subset composition, functional status, and spatial location of CD8+ TILs in relation to RFS in human breast tumors remain unclear. Spatial tissue analysis via quantitative immunofluorescence showed that infiltration of CD8+ T cells into cancer islands was more significantly...

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PMID: 31465302
DOI: 10.1172/jci.insight.130000

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