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Article

JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation

31 Oct 2018

Abstract excerpt

STUDY QUESTION: Is JUNO protein present at the surface membrane of human oocytes and involved in the fertilisation process? SUMMARY ANSWER: JUNO protein is expressed on the plasma membrane of human oocytes and its inhibition by a monoclonal antibody completely blocks gamete fusion. WHAT IS KNOWN ALREADY: Fusion of gamete membranes is the culminating event of the fertilisation process, but its molecular mechanisms...

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PMID: 30517645
DOI: 10.1093/humrep/dey340

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