Article

Mapping generalizable brain-based depression subtypes across clinical, cognitive, and neurotransmitter dimensions

2026-07-07

Abstract excerpt

Identifying generalizable brain-based biotypes across independent cohorts is critical for parsing heterogeneity in Major Depressive Disorder (MDD), yet robust subtypes spanning micro- and macroscales remain poorly defined. We applied stability-based clustering to cortical thickness data from 1,531 MDD individuals in UK Biobank (UKB), with external validation in 144 inpatients from IRCCS Ospedale San Raffaele (HSR)...

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Literature Corpus work: 5b05dcfa-8ce4-5b69-8def-9a5d9431e375
DOI: 10.64898/2026.06.25.26356577

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