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Evolutionary divergence and expression of differential HLA alleles between donor and recipient influence acute GVHD onset after allogenetic HSCT

2025-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Acute graft-versus-host disease (aGVHD) remains a major complication after hematopoietic stem cell transplantation (HSCT), especially given haploidentical HSCT is now China’s primary method, yet this context lacks reliable predictors. aGVHD initiation, involving donor T cell activation by recipient conventional dendritic cells (cDCs), depends on donor-recipient HLA disparity and its expression....

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Literature Corpus work
5531040b-72fe-553e-afa8-6ad92518dd9a
DOI
10.64898/2025.12.10.25342012
Open publication

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