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Article

Time-Lapse Epifluorescence Microscopy Imaging of Pseudomonas aeruginosa and Staphylococcus aureus Heterogeneous Phenotypes.

Journal of visualized experiments : JoVE - 14 Feb 2025

Hare Patricia J, Batchelder Jonathan I, LaGree Travis J, Mahey Nisha, Power Angela D, Wu Yi I, Mok Wendy W K

Abstract excerpt

Antibiotic persistence is a phenomenon in which a small number of bacterial cells in a genetically susceptible population survive antibiotic treatment that kills the other genetically identical cells. Bacterial persisters can resume replication once antibiotic treatment ends and are commonly thought to underlie clinical treatment failure. Recent work harnessing the power of time-lapse fluorescence microscopy, in...

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PMID: 40029821
DOI: 10.3791/67617
PMCID: PMC12320765

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