Dissecting Bacterial Growth Variants by Cellular Phenotypic Profiling and Backtracing.

Abstract excerpt

Bacterial cell populations are phenotypically heterogenous, including, e.g., exponentially growing cells, besides nonreplicating persisters that tolerate antibiotics, or so-called "viable-but non-culturable" cells. The lack of biomarkers and the dynamic, reversible nature of these cellular growth phenotypes make it challenging to differentiate them and study their underpinning molecular characteristics. Here, we...

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