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Article

Single-cell phenotypic profiling and backtracing exposes and predicts clinically relevant subpopulations in isogenic Staphylococcus aureus communities.

Communications biology - 1 Oct 2024

Hira Jonathan, Singh Bhupender, Halder Tirthankar, Mahmutovic Anel, Ajayi Clement, Sekh Arif Ahmed, Hegstad Kristin, Johannessen Mona, Lentz Christian S

Abstract excerpt

Isogenic bacterial cell populations are phenotypically heterogenous and may include subpopulations of antibiotic tolerant or heteroresistant cells. The reversibility of these phenotypes and lack of biomarkers to differentiate functionally different, but morphologically identical cells is a challenge for research and clinical detection. To overcome this, we present ´Cellular Phenotypic Profiling and backTracing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39354092
DOI: 10.1038/s42003-024-06894-z
PMCID: PMC11445386

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