Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.

Journal of human genetics - 1 Dec 2023

Li Haobo, Zhang Zhu, Qiu Yuting, Weng Haoyi, Yuan Shuai, Zhang Yunxia, Zhang Yu, Xi Linfeng, Xu Feiya, Ji Xiaofan, Hao Risheng, Yang Peiran, Chen Gang, Zuo Xianbo, Zhai Zhenguo, Wang Chen

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous risk loci for venous thromboembolism (VTE), but it is challenging to decipher the underlying mechanisms. We employed an integrative analytical pipeline to transform genetic associations to identify novel plasma proteins for VTE. Proteome-wide association studies (PWAS) were determined by functional summary-based imputation leveraging data from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Blood Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Proteome

Share to Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 37537391
DOI: 10.1038/s10038-023-01186-6
PMCID: PMC10678328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.PMID 37537391Read ↗

Plasma proteomics enhances genetic risk prediction and biological understanding of venous thromboembolismSemantic proximity Read ↗

Identification and genetic validation of potential therapeutic targets for pulmonary hypertension through multi-omics causal inference.Semantic proximity Read ↗

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases.Semantic proximity Read ↗

Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis.Semantic proximity Read ↗

Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity Read ↗

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics studySemantic proximity Read ↗

Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseasesSemantic proximity Read ↗

Causal insights into the role of metabolites in venous thromboembolism pathogenesis: a metabolome-wide Mendelian randomization study.Semantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.Semantic proximity Read ↗

Identification of Circulating Proteins Associated With Blood Pressure.Semantic proximity Read ↗

Identifying novel risk targets in inflammatory skin diseases by comprehensive proteome-wide Mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.