Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.

doi:10.1038/s44318-025-00381-9

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Article

Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.

The EMBO journal - 1 Apr 2025

Škapik Ivana Paskov, Giacomelli Chiara, Hahn Sarah, Deinlein Hanna, Gallant Peter, Diebold Mathias, Biayna Josep, Hendricks Anne, Olimski Leon, Otto Christoph, Kastner Carolin, Wolf Elmar, Schülein-Völk Christina, Maurus Katja, Rosenwald Andreas, Schleussner Nikolai, Jackstadt Rene-Filip, Schlegel Nicolas, Germer Christoph-Thomas, Bushell Martin, Eilers Martin, Schmidt Stefanie, Wiegering Armin

Abstract excerpt

Protein synthesis is an essential process, deregulated in multiple tumor types showing differential dependence on translation factors compared to untransformed tissue. We show that colorectal cancer (CRC) with loss-of-function mutation in the APC tumor suppressor depends on an oncogenic translation program regulated by the ability to sense phosphorylated eIF2α (p-eIF2α). Despite increased protein synthesis rates...

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Identifiers

PMID: 40016419
DOI: 10.1038/s44318-025-00381-9
PMCID: PMC11962125

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