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Article

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K.

eLife - 13 Dec 2021

Knight John Rp, Vlahov Nikola, Gay David M, Ridgway Rachel A, Faller William James, Proud Christopher, Mallucci Giovanna R, von der Haar Tobias, Smales Christopher Mark, Willis Anne E, Sansom Owen J

Abstract excerpt

Increased protein synthesis supports the rapid cell proliferation associated with cancer. The Rpl24Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here, we show that Rpl24Bst also suppresses tumorigenesis and proliferation in a model of colorectal cancer (CRC) with two common patient...

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Identifiers

PMID: 34895463
DOI: 10.7554/eLife.69729
PMCID: PMC8668188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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