Article

<i> Rpl24 <sup>Bst</sup> </i> mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

2021-05-05

Abstract excerpt

Increased protein synthesis supports the rapid proliferation associated with cancer. The Rpl24 Bst mutant mouse reduces the expression of the ribosomal protein RPL24 and has been used to suppress translation and limit tumorigenesis in multiple mouse models of cancer. Here we show that Rpl24 Bst also suppresses tumorigenesis and proliferation in a model of colorectal cancer with two common patient mutations, A...

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Literature Corpus work: 5be17644-94df-5a0c-99af-ce1b0b28cf04
DOI: 10.1101/2021.05.05.442715

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