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Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

26 Feb 2025

Abstract excerpt

BACKGROUND: Tumor resistance represents a major challenge in the current oncology landscape. Asparagine endopeptidase (AEP) overexpression correlates with worse prognosis and reduced overall survival in most human solid tumors. However, the underlying mechanisms of the connection between AEP and reduced overall survival in cancer patients remain unclear. METHODS: High-throughput proteomics, cellular and molecular...

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PMID: 40012043
DOI: 10.1186/s13046-025-03334-6

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