Article

The ATR inhibitor elimusertib exhibits anti-lymphoma activity and synergizes with the PI3K inhibitor copanlisib

2023-02-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> The DNA damage response (DDR) is the cellular process devoted to the preservation of an intact genome. The DDR is often deregulated in lymphoma cells due to high levels of DNA damage, tumor suppressor inactivation, increased replication stress observed after oncogene activation, or high amounts of reactive oxygen species. The ataxia telangiectasia and Rad3-related (ATR) kinase...

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Literature Corpus work: 2f2141e0-8a26-55ac-badc-051b7429d263
DOI: 10.1101/2023.02.10.528011

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