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Article

Untangling the ATR-CHEK1 network for prognostication, prediction and therapeutic target validation in breast cancer.

Molecular oncology - 1 Mar 2015

Abdel-Fatah Tarek M A, Middleton Fiona K, Arora Arvind, Agarwal Devika, Chen Tao, Moseley Paul M, Perry Christina, Doherty Rachel, Chan Stephen, Green Andrew R, Rakha Emad, Ball Graham, Ellis Ian O, Curtin Nicola J, Madhusudan Srinivasan

Abstract excerpt

ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 (Ser345) protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA expression was evaluated in 1950 breast cancers. Pre-clinically, biological consequences of ATR gene knock down...

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Source

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Identifiers

PMID: 25468710
DOI: 10.1016/j.molonc.2014.10.013
PMCID: PMC5528699

Genes

ATR
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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