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EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties

12 Sept 2021

Abstract excerpt

Enhanced DNA damage repair capacity attenuates cell killing of DNA-damaging chemotherapeutic agents. In silico analysis showed that epithelial membrane protein 3 (EMP3) is associated with favorable survival, and negatively regulates cell cycle S-phase. Consistently, loss and gain of function studies demonstrated that EMP3 inhibits breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like...

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PMID: 34511602
DOI: 10.1038/s41419-021-04140-6

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