Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci.

doi:10.1016/0027-5107(85)90137-x

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Article

Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci.

Mutation research - 1 Jan 2000

Leong P M, Thilly W G, Morgenthaler S

Abstract excerpt

The performance of mutation assays with single cells involves a series of separate steps beginning with the induction of mutant cells and ending with the counting of mutant and wild-type colonies. The variation among identically treated cultures is here modeled as arising from 3 sources: (1) the...

Topics

Cells, Cultured
Dose-Response Relationship, Drug
Humans
Lymphocytes
Mutagenicity Tests
Mutation
Research Design
Statistics as Topic

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