Article
Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci.
Mutation research - 1 Jan 2000
Leong P M, Thilly W G, Morgenthaler S
Abstract excerpt
The performance of mutation assays with single cells involves a series of separate steps beginning with the induction of mutant cells and ending with the counting of mutant and wild-type colonies. The variation among identically treated cultures is here modeled as arising from 3 sources: (1) the number of mutant cells surviving treatment, (2) the number of mutant cells sampled in steps of sampling and growth...
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