ProteoForge: An Imputation-Aware Framework for Differential Proteoform Discovery in Bottom-Up Proteomics

Abstract excerpt

The human genome contains approximately 20,000 protein-coding genes. However, millions of diverse protein variants, called proteoforms, exist. Despite originating from the same gene, proteoforms often have distinct biological roles. In bottom-up proteomics, the aggregation of peptide measurements into protein-level quantities often obscures this information. Existing methods for proteoform deconvolution are limite...

Topics

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• Alternative Splicing
• Databases, Protein
• Gene Ontology
• Molecular Sequence Annotation
• Protein Isoforms
• Protein Processing, Post-Translational
• Proteome
• User-Computer Interface

Identifiers and source

Literature Corpus work

e86a71b1-7fea-528d-a5de-18ef43cfd879

DOI

10.64898/2025.12.12.694008