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Article

Assessing technical and biological variation in SWATH-MS-based proteomic analysis of chronic lymphocytic leukaemia cells.

Scientific reports - 3 Feb 2021

Eagle Gina L, Herbert John M J, Zhuang Jianguo, Oates Melanie, Khan Umair T, Kitteringham Neil R, Clarke Kim, Park B Kevin, Pettitt Andrew R, Jenkins Rosalind E, Falciani Francesco

Abstract excerpt

Chronic lymphocytic leukaemia (CLL) exhibits variable clinical course and response to therapy, but the molecular basis of this variability remains incompletely understood. Data independent acquisition (DIA)-MS technologies, such as SWATH (Sequential Windowed Acquisition of all THeoretical fragments), provide an opportunity to study the pathophysiology of CLL at the proteome level. Here, a CLL-specific spectral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Receptors, Antigen, B-Cell

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Source

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Identifiers

PMID: 33536534
DOI: 10.1038/s41598-021-82609-2
PMCID: PMC7858606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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