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Distinct Single-cell Immune Ecosystems Distinguish True and <i>De Novo</i> HBV-related Hepatocellular Carcinoma Recurrences

2022-06-04

Abstract excerpt

<h4>Summary</h4> Revealing differential tumor immune microenvironment (TIME) characteristics between true versus de novo hepatocellular carcinoma (HCC) recurrence could help optimal development and use of immunotherapies. Here, we studied the TIME of recurrent HBV-related HCCs by 5’and VDJ single-cell and bulk RNA-sequencing, flow cytometry, and multiplexed immunofluorescence. Analyses of mutational profiles, ev...

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Literature Corpus work
072d364e-41eb-5413-a654-b298cac58dbd
DOI
10.1101/2022.06.02.494526
Open publication

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Distinct Single-cell Immune Ecosystems Distinguish True and <i>De Novo</i> HBV-related Hepatocellular Carcinoma RecurrencesDOI 10.1101/2022.06.02.494526
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