Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma.

doi:10.1016/j.cell.2020.11.041

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma.

Cell - 21 Jan 2021

Sun Yunfan, Wu Liang, Zhong Yu, Zhou Kaiqian, Hou Yong, Wang Zifei, Zhang Zefan, Xie Jiarui, Wang Chunqing, Chen Dandan, Huang Yaling, Wei Xiaochan, Shi Yinghong, Zhao Zhikun, Li Yuehua, Guo Ziwei, Yu Qichao, Xu Liqin, Volpe Giacomo, Qiu Shuangjian, Zhou Jian, Ward Carl, Sun Huichuan, Yin Ye, Xu Xun, Wang Xiangdong, Esteban Miguel A, Yang Huanming, Wang Jian, Dean Michael, Zhang Yaguang, Liu Shiping, Yang Xinrong, Fan Jia

Abstract excerpt

Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell profiling in relapsed HCC may aid in the design of effective anticancer therapies, including immunotherapies. We profiled the transcriptomes of ∼17,000 cells from 18 primary or early-relapse HCC cases. Early-relapse tumors have reduced levels of regulatory T cells, increased dendritic cells (DCs), and increased infiltrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to RNA-Seq

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Single-Cell Analysis

Share to Carcinoma, Hepatocellular

Share to CD8-Positive T-Lymphocytes

Share to Killer Cells, Natural

Share to Myeloid Cells

Share to Neoplasm Recurrence, Local

Share to Tumor Microenvironment

Source

Open in PubMed

Identifiers

PMID: 33357445
DOI: 10.1016/j.cell.2020.11.041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma.PMID 33357445Read ↗

Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrencesSemantic proximity Read ↗

Distinct Single-cell Immune Ecosystems Distinguish True and <i>De Novo</i> HBV-related Hepatocellular Carcinoma RecurrencesSemantic proximity Read ↗

Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progressionSemantic proximity Read ↗

High ratio of resident to exhausted CD4+ T cells predicts favorable prognosis and potentially better immunotherapeutic efficacy in hepatocellular carcinomaSemantic proximity Read ↗

Identification of the CD8+T-cell exhaustion signature of Hepatocellular Carcinoma for the Prediction of prognosis and Immune microenvironment by Integrated Analysis of Bulk- and Single-Cell RNA Sequencing DataSemantic proximity Read ↗

Bulk and single‐cell transcriptome reveal the immuno‐prognostic subtypes and tumour microenvironment heterogeneity in HCCSemantic proximity Read ↗

Integrated analysis of single-cell and bulk RNA sequencing data reveals a CD8+ T cells signature predicting prognosis and immunotherapy response in hepatocellular carcinomaSemantic proximity Read ↗

Single-cell atlas of diverse immune populations in the advanced biliary tract cancer microenvironmentSemantic proximity Read ↗

T-cell exhaustion signatures characterize the immune landscape and predict HCC prognosis via integrating single-cell RNA-seq and bulk RNA-sequencingSemantic proximity Read ↗

Atypical memory B cells acquire Breg phenotypes in hepatocellular carcinoma.Semantic proximity Read ↗

PNOC Expressed by B Cells in Cholangiocarcinoma Was Survival Related and LAIR2 Could Be a T Cell Exhaustion Biomarker in Tumor Microenvironment: Characterization of Immune Microenvironment Combining Single-Cell and Bulk Sequencing TechnologySemantic proximity Read ↗

Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.