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Increased Trophoblast Cell Ferroptosis via HMGB1/ACSL4 Pathway Is Associated with Spontaneous Abortion

24 Feb 2025

Abstract excerpt

Abstract Introduction Trophoblast cells undergo ferroptosis in pregnancy-related diseases. HMGB1 participates in pathological ferroptosis. However, whether lipopolysaccharide (LPS) -mediated HMGB1 expression induces the ferroptosis of trophoblast cells and further spontaneous abortion (SA) remains unknown. Methods HMGB1 and ACSL4 expression were measured in villous tissues from 20 women with SA and 20 women with...

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PMID: 39994144
DOI: 10.1007/s43032-025-01817-7

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Increased Trophoblast Cell Ferroptosis via HMGB1/ACSL4 Pathway Is Associated with Spontaneous AbortionPMID 39994144Read ↗

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