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Causal relationship between MIF/MCSF and Spontaneous Abortion: Insights from Mendelian Randomization and population Validation

2025-08-07

Abstract excerpt

<h4>Objective: </h4> : Spontaneous abortion (SA) affects 15-25% of clinically recognized pregnancies. Immune dysregulation is linked to SA pathogenesis, however, causal relationships between specific inflammatory cytokines and SA remain unclear. <h4>Methods: </h4>: Two-sample Mendelian randomization (MR) analysis was performed using SA data from FinnGen (20,775 SA cases, 180,063 controls), and the genetic associa...

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Literature Corpus work
2d41ac54-d395-501a-8c71-c3bc9db53b08
DOI
10.22541/au.175454652.28794630/v1
Open publication

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