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PLA2G6 guards placental trophoblasts against ferroptotic injury

21 Oct 2020

Abstract excerpt

The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxy-arachidonoyl (C20:4)- or adrenoyl (C22:4)- phosphatidylethanolamine (Hp-PE). The selenium-dependent glutathione peroxidase 4 (GPX4) inhibits ferroptosis, converting unstable ferroptotic lipid hydroperoxides to nontoxic lipid alcohols in a tissue-specific manner. While placental oxidative stress and...

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PMID: 33087576
DOI: 10.1073/pnas.2009201117

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