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HMGB1 promotes immune abnormalities in preeclampsia by recruiting monocyte/decidual macrophages and inducing M1 polarization

26 Mar 2025

Abstract excerpt

Preeclampsia (PE) is a severe pregnancy complication, characterized by immune dysregulation and placental hypoxia. Decidua macrophages (dMφ) are essential at maternal-fetal interface, involves aberrant activation of dMφ toward the M1 phenotype in PE. High mobility group box 1 (HMGB1), released from necrotic cells after injury, accumulates in the placenta and peripheral blood of patients with PE. This study aims...

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PMID: 40143409
DOI: 10.1093/biolre/ioaf061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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