Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion

Abstract excerpt

BACKGROUND: The survival of decidual stromal cells (DSCs) at the maternal-fetal interface is critical for maintaining pregnancy. Dysfunction of DSCs is a significant contributor to recurrent spontaneous abortion (RSA), though the precise regulatory mechanisms remain elusive. Here, we report a marked downregulation of fatty acid-binding protein 5 (FABP5) in decidual tissues and DSCs from RSA donors, suggesting its...

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