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Article

Metabolic Phenotype of Stage 1 and Stage 2 Type 1 Diabetes Using Modeling of β Cell Function.

The Journal of clinical endocrinology and metabolism - 16 Oct 2025

Galderisi Alfonso, Bonet Jacopo, Ismail Heba M, Moran Antoinette, Fiorina Paolo, Bosi Emanuele, Petrelli Alessandra

Abstract excerpt

BACKGROUND: Staging preclinical type 1 diabetes (T1D) and monitoring the response to disease-modifying treatments rely on the oral glucose tolerance test (OGTT). However, it is unknown whether OGTT-derived measures of beta cell function can detect subtle changes in metabolic phenotype, thus limiting their usability as endpoints in prevention trials. OBJECTIVE: To describe the metabolic phenotype of people with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39992257
DOI: 10.1210/clinem/dgaf086
PMCID: PMC12527456

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