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Article

Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes.

Nature medicine - 1 Jan 2021

Wagner Robert, Heni Martin, Tabák Adam G, Machann Jürgen, Schick Fritz, Randrianarisoa Elko, Hrabě de Angelis Martin, Birkenfeld Andreas L, Stefan Norbert, Peter Andreas, Häring Hans-Ulrich, Fritsche Andreas

Abstract excerpt

The state of intermediate hyperglycemia is indicative of elevated risk of developing type 2 diabetes1. However, the current definition of prediabetes neither reflects subphenotypes of pathophysiology of type 2 diabetes nor is predictive of future metabolic trajectories. We used partitioning on variables derived from oral glucose tolerance tests, MRI-measured body fat distribution, liver fat content and genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 33398163
DOI: 10.1038/s41591-020-1116-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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