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Article

Metabolic heterogeneity at the onset of type 2 diabetes: phenotypes of insulin resistance and β-cell function in the Kazakh population.

Frontiers in endocrinology - 1 Jan 2026

Tleumagambetova Bibigul, Kosmuratova Raikul, Kudabayeva Khatimya, Bazargaliyev Yerlan

Abstract excerpt

Background: Type 2 diabetes mellitus (T2DM) is increasingly recognized as a heterogeneous metabolic disorder characterized by varying contributions of insulin resistance and pancreatic β-cell dysfunction. However, data on early metabolic phenotypes at diagnosis remain limited in Central Asian populations. Methods: In this cross-sectional study, 240 adults with newly diagnosed T2DM were recruited from primary...

Read the complete abstract on PubMed

Topics

Humans
Diabetes Mellitus, Type 2
Insulin Resistance
Insulin-Secreting Cells
Female
Cross-Sectional Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Phenotype

Kazakhstan

Male

Middle Aged

Adult

Autoantibodies

Source

Open in PubMed Open full text

Identifiers

PMID: 42712388
DOI: 10.3389/fendo.2026.1824856
PMCID: PMC13549826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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