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Megakaryocytes as the Regulator of the Hematopoietic Vascular Niche

22 Jun 2022

Abstract excerpt

Megakaryocytes (MKs) are important components of the hematopoietic niche. Compared to the non-hematopoietic niche cells, MKs serving as part of the hematopoietic niche provides a mechanism for feedback regulation of hematopoietic stem cells (HSCs), in which HSC progeny (MKs) can modulate HSC adaptation to hematopoietic demands during both steady-state and stress hematopoiesis. MKs are often located adjacent to...

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PMID: 35814384
DOI: 10.3389/fonc.2022.912060

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