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Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential Targets

25 Nov 2022

Abstract excerpt

Platelets are small, anucleate cellular fragments, which are produced by megakaryocytes, and play a key role in hemostasis and thrombus formation. The differentiation of megakaryocytes from hematopoietic stem cells in bone marrow and the development of megakaryocytes into platelets is a complex process. Various regulatory factorsin megakaryopoiesis including cytokines, growth factors, transcription factors, and...

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PMID: 36472109
DOI: 10.31083/j.fbl2711313

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