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ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2

22 Feb 2025

Abstract excerpt

OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of type 2 diabetes mellitus (DM). The transcription factor zinc fingers and homeoboxes 2 (ZHX2) has been implicated in the pathogenesis of chronic liver diseases, yet its precise role and underlying mechanism in DM-induced hepatic injury remain poorly elucidated. METHODS: To investigate this, we used a high-fat...

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PMID: 39987125
DOI: 10.1038/s41387-025-00355-0

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