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USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro

18 Feb 2025

Abstract excerpt

Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates many critical genes associated with iron storage and transportation, the activity of which is influenced by E3 ligase-mediated ubiquitination. We wondered whether there is a deubiquitinase that mediates the deubiquitination of Nrf2 to stabilize Nrf2 expression and further prevent diabetic kidney disease (DKD). High glucose (HG) was applied to induce an...

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PMID: 39967230
DOI: 10.1080/0886022x.2025.2458761

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