Article
Hepatic F-Box Protein FBXW7 Maintains Glucose Homeostasis Through Degradation of Fetuin-A.
Diabetes - 1 May 2018
Zhao Jiejie, Xiong Xuelian, Li Yao, Liu Xing, Wang Tao, Zhang Hong, Jiao Yang, Jiang Jingjing, Zhang Huijie, Tang Qiqun, Gao Xin, Li Xuejun, Lu Yan, Liu Bin, Hu Cheng, Li Xiaoying
Abstract excerpt
Type 2 diabetes mellitus (T2DM) has become one of the most serious and long-term threats to human health. However, the molecular mechanism that links obesity to insulin resistance remains largely unknown. Here, we show that F-box and WD repeat domain-containing 7 (FBXW7), an E3 ubiquitin protein ligase, is markedly downregulated in the liver of two obese mouse models and obese human subjects. We further identify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.