Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metformin ameliorates gestational diabetes mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathway

1 Feb 2025

Abstract excerpt

Both mothers and infants experience oxidative stress due to gestational diabetes mellitus (GDM), which is strongly associated with adverse pregnancy outcomes. Ferroptosis, a novel form of programmed cell death characterized by iron-dependent lipid peroxidation, is believed to play a critical role in the pathogenesis and progression of GDM. Metformin (MET) has shown potential in alleviating oxidative stress;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Birth, Development, and Health
Share to Gestational Diabetes Research and Management
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39959960
DOI: 10.1080/10715762.2025.2468737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metformin ameliorates gestational diabetes mellitus via inhibiting ferroptosis of trophoblasts through the Nrf2/HO-1 signaling pathwayPMID 39959960Read ↗

Gestational diabetes mellitus affects placental iron homeostasis: Mechanism and clinical implicationsSemantic proximity Read ↗

The Role of Oxidative Stress in the Pathophysiology of Gestational Diabetes MellitusSemantic proximity Read ↗

p66Shc-mediated oxidative stress is involved in gestational diabetes mellitusSemantic proximity Read ↗

Cellular and Molecular Pathophysiology of Gestational DiabetesSemantic proximity Read ↗

The Emerging Roles of Ferroptosis and NETosis in Pregnancy Complications: Insights into Preeclampsia and Gestational Diabetes MellitusSemantic proximity Read ↗

Ferroptosis and its potential role in gestational diabetes mellitus: updated evidence from pathogenesis to therapySemantic proximity Read ↗

Mechanism of Placenta Damage in Gestational Diabetes Mellitus by Investigating TXNIP of Patient Samples and Gene Functional Research in Cell LineSemantic proximity Read ↗

GLUT1 exacerbates trophoblast ferroptosis by modulating AMPK/ACC mediated lipid metabolism and promotes gestational diabetes mellitus associated fetal growth restrictionSemantic proximity Read ↗

Bioinformatics-based Identification of Ferroptosis-related Genes and their Diagnostic Value in Gestational Diabetes MellitusSemantic proximity Read ↗

Focus on Cell Apoptosis, Pyroptosis and Ferroptosis to Explore Strategic Breakthrough for GDMSemantic proximity Read ↗

Ferroptosis and iron metabolism in diabetes: Pathogenesis, associated complications, and therapeutic implicationsSemantic proximity Read ↗

Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.