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CYP450 Genotype—Phenotype Concordance Using the Geneva Micrococktail in a Clinical Setting

26 Aug 2021

Abstract excerpt

Pharmacokinetic variability is a major source of differences in drug response and can be due to genetic variants and/or drug-drug interactions. Cytochromes P450 are among the most studied enzymes from a pharmacokinetic point of view. Their activity can be measured by phenotyping, and/or predicted by genotyping. Depending on the presence of drugs and/or diseases that can affect their in vivo activity, both...

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PMID: 34512355
DOI: 10.3389/fphar.2021.730637

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