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Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma

30 May 2022

Abstract excerpt

BACKGROUND: Malignant pleural mesothelioma (MPM) has a poor overall survival with few treatment options. Whole genome sequencing (WGS) combined with the immune features of MPM offers the prospect of identifying changes that could inform future clinical trials. METHODS: We analysed somatic mutations from 229 MPM samples, including previously published data and 58 samples that had undergone WGS within this study....

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PMID: 35637530
DOI: 10.1186/s13073-022-01060-8

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