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Immune Microenvironment and Genetics in Malignant Pleural Mesothelioma

11 Jun 2021

Abstract excerpt

Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with limited therapeutic options beyond surgery and cytotoxic chemotherapy. The success of immune checkpoint inhibition has been found to correlate with expression of immune-related genes such as CD274 (PD-L1) in lung and other solid cancers. However, only a small subset of MPM patients respond to checkpoint inhibition, and this response has...

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PMID: 34178677
DOI: 10.3389/fonc.2021.684025

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