Article
The mosaicism of Cas-induced mutations and pleiotropic effects of scarlet gene in an emerging model system.
Heredity - 1 Apr 2025
Xu Sen, Neupane Swatantra, Wang Hongjun, Pham Thinh Phu, Snyman Marelize, Huynh Trung V, Wang Li
Abstract excerpt
The effective use of CRISPR technologies in emerging model organisms faces significant challenges in efficiently generating heritable mutations and in understanding the genomic consequences of induced DNA damages and the inheritance patterns of induced mutations. This study addresses these issues by 1) developing an efficient microinjection delivery method for gene editing in the microcrustacean Daphnia pulex; 2)...
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